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The noninvasive assessment of diastolic function is an integral component of any examination of the heart via echocardiography. Mild DD, although prevalent, did not affect survival rate. However, after propensity matching, only moderate and severe DD were associated with an increased mortality risk (hazard ratio, 1.58 95% confidence interval, 1.20-2.08 and hazard ratio, 1.84 1.29-2.62, respectively P <.001 for each).Ĭonclusions In this single-center study of patients with normal ejection fraction who presented for outpatient echocardiography, the presence of moderate or severe DD was an independent predictor of mortality. The unadjusted survival rate was worse according to the presence and degree of DD ( P <.001). A total of 5789 deaths occurred during the follow-up period.

In 65.2% of the cohort, DD was present, with mild DD being the most prevalent type of dysfunction. Results A total of 36 261 patients were identified (mean age, 58.3 years 54.4% female) with a mean (SD) follow-up time of 6.2 (2.3) years. Propensity analysis was performed to compare outcomes among the groups. Diastolic function was graded using echocardiographic Doppler variables designated as normal, mild (grade I, ie, impaired relaxation pattern), moderate (grade II, ie, pseudonormal pattern), or severe (grade III, ie, restrictive filling pattern) dysfunction. Methods We reviewed clinical records and echocardiographic findings of consecutive patients who underwent an outpatient echocardiogram that revealed normal systolic function (ejection fraction, ≥55%) from January 1, 1996, through December 31, 2005. However, few prognostic data exist regarding the effect of DD in patients with normal systolic function. Shared Decision Making and Communicationīackground Diastolic dysfunction (DD) is known to be associated with increased mortality rate in the presence of impaired systolic function.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.

Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography.

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